Unifarm University Consortium (Consorzio Universitario Unifarm, UNIFARM) was founded in Catania in 2002 by Filippo Drago, Professor of Pharmacology at the School of Medicine, University of Catania, in cooperation with the University of Catania and twelve major multinational pharmaceutical companies. In the same year the Research Centre in Clinical Pharmacology the first in Central...read more

UNIFARM is a CRO registered at  the Agenzia Italiana del Farmaco (Italian Authority for Drugs, AIFA), compliant with the requirements of the DM (Ministerial Decree) dated March 31, 2008 on clinical trials and therefore able to provide services such as: clinical study design; project management; preparation of study protocols and other regulatory documents; approval procedures...read more

UNIFARM has implemented a Quality System in line with national and international regulations to ensure high level of service and client satisfaction. Indeed, this is one of the main objectives of UNIFARM and is constantly pursued through the involvement of all the personnel in a quality process based on the assumption of individual responsibility, as well as through the implementation of systems and procedures...read more

Isoflavones: estrogenic activity, biological effect and bioavailability.

Isoflavones are phytoestrogens with potent estrogenic activity; genistein, daidzein and glycitein are the most active isoflavones found in soy beans. Phytoestrogens have similarity in structure with the human female hormone 17-β-estradiol, which can bind to both alpha and beta estrogen receptors, and mimic the action of estrogens on target organs, thereby exerting many health benefits when used in some hormone-dependent diseases. Numerous clinical studies claim benefits of genistein and daidzein in chemoprevention of breast and prostate cancer, cardiovascular disease and osteoporosis as well as in relieving postmenopausal symptoms.The ability of isoflavones to prevent cancer and other chronic diseases largely depends on pharmacokinetic properties of these compounds, in particular absorption and distribution to the target tissue. The chemical form in which isoflavones occur is important because it influences their bioavailability and, therefore, their biological activity. Glucose-conjugated isoflavones are highly polar, water-soluble compounds. They are hardly absorbed by the intestinal epithelium and have weaker biological activities than the corresponding aglycone. Different microbial families of colon can transform glycosylated isoflavones into aglycones. Clinical studies show important differences between the aglycone and conjugated forms of genistein and daidzein. The evaluation of isoflavone metabolism and bioavailability is crucial to understanding their biological effects. Lipid-based formulations such as drug incorporation into oils, emulsions and self-microemulsifying formulations have been introduced to increase bioavailability. Complexation with cyclodextrin also represent a valid method to improve the physicochemical characteristics of these substances in order to be absorbed and distributed to target tissues. We review and discuss pharmacokinetic issues that critically influence the biological activity of isoflavones.


http://link.springer.com/article/10.1007%2Fs13318-012-0112-y

 

Unifarm è un Centro di Saggio (CdS) certificato dal Ministero della Salute,
in Buona Pratica di Laboratorio (BPL)